Local media reported that the two Albanians, Ervis Markja, 26, and Adriatik Gega, 28, escaped from the high security prison at Carinola, at around 03:00 o'clock in the morning.
The dynamics of the event and the methods used by the Albanians have not yet been known.
Meanwhile controls are being carried out by police forces at railway and public transport stations, because it is suspected that they may try to leave by train or bus.
The media say Ervis Markja was arrested in January 2016 along with two other people, identified after an escape in which they had attacked a police car.
He was arrested in Carinola for robbery and resistance to a police official.
While Adriatico Gega was arrested in 2012 in the province of Benevento. At that time, he was about 20 years old and was accused of being part of a home-based robbery gang along with three others detained with him.